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Research Expertise

Mixed and Analog Bio-Circuit Design

posted Jan 21, 2014, 1:38 PM by Amine Miled   [ updated Jan 21, 2014, 1:38 PM by Amine M ]

We are working toward fully integrated CMOS interface dedicated for cells manipulation and separation in LoC devices. The interface includes all microelectronics circuits for dielectrophoretic manipulation and capacitive detection. It contains also an embedded frequency and phase micro controller to ensure different type of cells displacements such as rotation, translation and separation with a wide tunable frequency band of 250 kHz for LoC applications. Furthermore, the detection part is a charge-based capacitive measurement circuit with a high sensitivity of 10 mV for each 1 fF. This new chip is part of a LoC device including both the microfluidic and the microelectronics chips.

New Packaging Techniques for Hybrid Microsystems

posted Jan 21, 2014, 1:32 PM by Amine Miled   [ updated Jan 21, 2014, 1:32 PM by Amine M ]

Our research expertise targets new packaging technique 
ifor hybrid microelectronics / microfluidic microsystems. We targetting very thin LoC including microchannels and complementary-metal-oxide semiconductor (CMOS) chip. We use glass, PDMS, silicon, epoxies and other type materials. Our previous device has a thickness of 0.5 mm. The size of the device is 5 mm x  5 mm including 64 L-shaped electrodes. It was connected to a printed circuit board for cell manipulation using dielectrophoresis. The device also includes a new polydimethylsiloxane (PDMS)-based packaging technique to protect the integrated circuit (IC) from liquid leakage, in addition to a fast tubing process. The designed LoC requires only 2 picoliters as sample volume. Different packaging scenarios were tested using ultraviolet light and conventional epoxy, as well as PDMS and commercial connectors

New Low-Cost and Fast Micro-fabrication Methods for Lab-on-chip Devices (Micro-electrode Array)

posted Jan 21, 2014, 1:11 PM by Amine Miled   [ updated Jan 21, 2014, 5:50 PM by Amine M ]

Our expertise covers also the development of new microfabrication techniques for LoC and hybrid microsystems. Our research is mainly focusing on microfabrication techniques using dicing and lasers. In order to protect our environment and our natural ressources, we promote techniques leading to reusable and reconfigurable microfuidic/microelectronics systems.


Dielectrophoretic Manipulations

posted Jan 21, 2014, 12:53 PM by Amine Miled   [ updated Jan 21, 2014, 1:03 PM by Amine M ]

Our expertise targets 
implantable/portable Laboratory-on-Chip (LoC) for dielectrophoretic manipulation and capacitive sensing of nano and micro particles or cells. Previous designed LoC has low static power consumption up to 650 μA with a voltage supply of −1.10 and +1.8 V.  U-shaped, L-shaped and octagonal electrodes are used to perform the separation and mixing operations. The biosensing part is designed with a charge based capacitive sensor with an integrated sigma-delta modulator in the output stage. It was tested experimentally with algae. The chip size is 1.2 by 1.2 mm and it is connected to a 15 × 30 mm microfluidic chip.

Particle Displacement Modelling in Microchannel

posted Jan 21, 2014, 12:42 PM by Amine Miled   [ updated Jan 21, 2014, 12:50 PM by Amine M ]

New modeling approaches for in-channel particle manipulation based on finite element modeling and multiphysic simulation. Our research goes toward more complex modelling techniques covering several types of manipulations such as magnetophoresis and optics. Our modeling approach is based on a hybrid interface using both FEM and MATLAB to link the propagation of the electrical field in the micro-channel to the particle motion. ANSYS/Comsol are used to simulate the electrical field propagation while MATLAB interprets the results to calculate cell displacement. The beta version of the proposed technique takes into account particle shape, weight and its electrical properties. Others methods and approaches are being developed in order to understand particle behaviour in biological liquid suach as CSF.
MDPI Sensors'13

Microfluidic-based Lab-on-Chip for Biosensors and Actuators

posted Jan 21, 2014, 12:26 PM by Amine Miled   [ updated Jan 21, 2014, 1:45 PM by Amine M ]

Our research is focusing on hybrid microelectronics / microfluidic Lab-on-Chip (LoC) platform for implantable/portable medical microsystems inorder to develop a low-voltage
 biosensing devices. targeted devices can handle particle mixing enabling reaction between different particles, liquid sampling and high sensitivity and precision biosensors. The system dimensions are reduced to the minimum size such as it requires only few sub-picolitre liquid samples. 

New Methods to Understand Brain Chemical Disorders

posted Jan 21, 2014, 12:17 PM by Amine Miled   [ updated Jan 21, 2014, 12:45 PM by Amine M ]

Study of the effect of neurotransmitter concentrations on the local conductivity and impedance of the cerebrospinal fluid in addition to their biological effects. Different neurotransmitters are analysed such as glutamate and gamma-Aminobutyric acid (GABA), which are the major excitatory and inhibitory neurotransmitters respectively, and dopamine, which is involved in many psychiatric disorders such as Parkinson’s disease, drug’s addiction and schizophrenia.

Extracted fro6th International IEEE EMBS Conference on Neural Engineering

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