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LABioTRON Invited Talk in York University, ON, Canada

posted Oct 21, 2009, 8:58 AM by Amine Miled   [ updated Jan 13, 2014, 9:24 PM ]

"Toward Automated Lab-on-Chip for Brain Monitoring Major Advances and Challenges", A.Miled,

Lab-on-Chip (LoC) are in their way to become the new biomedical standard. This talk covers the new development and extended use of LoC, to integrate new technologies. The objective is to design a LoC with new functions for a fully autonomous device. A micro particle separation was achieved through the monitoring of electrical field propagation, frequency, phase, and amplitude using different architectures of electrodes.

Our objective is to propose new diagnostic tools for a better understanding of neurodegenerative diseases. We also came up with an innovative approach to give a greater flexibility to the modeling of LoCs. This approach consists of modeling the behavior of particles based on the architectural design of the electrodes, the applied signals, and the biological properties of the medium. This modeling technique is based on a hybrid approach including a finite element modeling using ANSYS, and an algorithm implemented on Matlab. Then it was possible to calculate each particle's 3D position in a micro channel based on the results provided by ANSYS, which is not possible based on experimental results.

Also, we built this system entirely with a 3D architecture using heterogeneous technologies including a microfluidic chip, a Bluetooth wireless unit, and an embedded power supply module. The whole microelectronic part of the LoC is designed with CMOS 0.18 um TSMC technology. The microfluidic architecture was fabricated with a new microfabrication process using femto laser and high accuracy dicing saw.

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